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The wheat reference genome sequence (IWGSC RefSeq v1.0 & v2.1) has provided a foundation that has propelled recent advances in research and improvement of wheat. For the Structural and Functional Genomics Workshop, continued advances in research and understanding will require new experimental and computational approaches to structurally identify and assign function to genes (both coding and non-coding) as well as regulatory elements and epigenetic states. Accordingly, abstracts submitted for this workshop should focus on genome-scale studies that improve understanding of wheat genome function through the development of additional data resources, computational and experimental studies, exploration of gene families and pathways, and platforms that facilitate annotation and visualization.